Here i suggest posting small secrets or just actions for experienced players.
I will start.
1)
how to expand station coverage.In common situation we have a 18-tile
station coverage (10 tiles+4 from each side to cover.) Using airports
(can be enabled in settings => configure patches => interface)
and docks, we can expand this coverage.
International airport is
especially efficient in this case, cause it has 8-tile coverage to each
side. so we have 23-tile coverage as a result.

This also helps to combine goods accepting buildings of 2 nearby towns.
2)It
is rather hard to build signals 1 by 1. If we build 1 signal of needed
type, press 'ctrl' and move 1 tile to the side where we want such
signals, TTD will automatically build them to 1st crossing.